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副甲状腺ホルモン受容体遺伝子発現に対する低カルシウム食飼育の影響
https://ohu-lib.repo.nii.ac.jp/records/2155
https://ohu-lib.repo.nii.ac.jp/records/2155e40bc572-f002-434b-b259-109824409f2e
名前 / ファイル | ライセンス | アクション |
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KJ00000731678.pdf (521.1 kB)
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Item type | 紀要論文(ELS)_JAIRO Cloud(WEKO3)対応_596d4a9f(1) | |||||
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公開日 | 2003-06-30 | |||||
タイトル | ||||||
タイトル | 副甲状腺ホルモン受容体遺伝子発現に対する低カルシウム食飼育の影響 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Effect of Low Calcium Diet on Parathyroid Hormone Receptor Gene Expression | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | parathyroid hormone receptor | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | 1,25-dihydroxyvitamin D_3 | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | bone | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | kidney | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
ページ属性 | ||||||
内容記述タイプ | Other | |||||
内容記述 | P(論文) | |||||
記事種別(日) | ||||||
値 | 原著論文 | |||||
記事種別(英) | ||||||
言語 | en | |||||
値 | Original Article | |||||
著者名(日) |
川根, 徹也
× 川根, 徹也× 原元, 信貴× 伊藤, 秀文× 堀内, 登 |
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著者名よみ |
カワネ, テツヤ
× カワネ, テツヤ× ハラモト, ノブタカ× イトウ, ヒデフミ× ホリウチ, ノブル |
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著者名(英) |
KAWANE, Tetsuya
× KAWANE, Tetsuya× HARAMOTO, Nobutaka× ITOH, Hidefumi× HORIUCHI, Noboru |
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著者所属(日) | ||||||
値 | 奥羽大学歯学部口腔生化学講座 | |||||
著者所属(日) | ||||||
値 | 奥羽大学歯学部口腔生化学講座 | |||||
著者所属(日) | ||||||
値 | 奥羽大学歯学部口腔生化学講座 | |||||
著者所属(日) | ||||||
値 | 奥羽大学歯学部口腔生化学講座 | |||||
著者所属(英) | ||||||
言語 | en | |||||
値 | Department of Biochemistry, Ohu University School of Dentistry | |||||
著者所属(英) | ||||||
言語 | en | |||||
値 | Department of Biochemistry, Ohu University School of Dentistry | |||||
著者所属(英) | ||||||
言語 | en | |||||
値 | Department of Biochemistry, Ohu University School of Dentistry | |||||
著者所属(英) | ||||||
言語 | en | |||||
値 | Department of Biochemistry, Ohu University School of Dentistry | |||||
抄録(英) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Parathyroid hormone (PTH) acts on bone and kidney by binding to PTH/PTH-related protein receptor (PTH1R) and regulate calcium (Ca) and phosphorous (P) homeostasis. This experiment was undertaken to investigate the effect of Ca and vitamin D restriction (-Ca-D) diet on PTH1R mRNA expression in the major PTH target tissues such as bone and kidney. Rats fed -Ca-D diet showed significant decrease in serum Ca and P on day 14 and day 7, respectively. Serum PTH and 1, 25 dihydroxyvitamin D_3[1,25(OH)_2D_3] markedly increased on day 14 and day 1, respectively. Renal VitaminD-1 a-hydroxylase activities increased slightly during day 1-7 and markedly during day 14-35. PTH1R mRNA abundance determined by Northern blot analysis did not change in bone and kidney, when rats were fed -Ca-D diet for up to 14 days. These results suggest that down-regulation of PTH1R in PTH target tissues is due to degradation, internalization and desensitization of the receptor protein without transcriptional attenuation. | |||||
雑誌書誌ID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN1010214X | |||||
書誌情報 |
奥羽大学歯学誌 巻 30, 号 2, p. 163-167, 発行日 2003-06-30 |