WEKO3
アイテム
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口腔内カンジダ症の免疫学的研究 : Candida albicans菌体成分の免疫応答への作用
https://ohu-lib.repo.nii.ac.jp/records/2274
https://ohu-lib.repo.nii.ac.jp/records/2274839c152c-00ef-44ad-bc19-fb2a4cb527b3
名前 / ファイル | ライセンス | アクション |
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KJ00004260479.pdf (853.0 kB)
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Item type | 紀要論文(ELS)_JAIRO Cloud(WEKO3)対応_596d4a9f(1) | |||||
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公開日 | 2004-06-30 | |||||
タイトル | ||||||
タイトル | 口腔内カンジダ症の免疫学的研究 : Candida albicans菌体成分の免疫応答への作用 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Effect of Cell Components from Candida albicans on Immune Response | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Candida albicans | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | suppressive effects | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Th2 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
ページ属性 | ||||||
内容記述タイプ | Other | |||||
内容記述 | P(論文) | |||||
記事種別(日) | ||||||
値 | 原著論文 | |||||
記事種別(英) | ||||||
言語 | en | |||||
値 | Original Article | |||||
著者名(日) |
北村, 和典
× 北村, 和典 |
|||||
著者名よみ |
キタムラ, カズノリ
× キタムラ, カズノリ |
|||||
著者名(英) |
KITAMURA, Kazunori
× KITAMURA, Kazunori |
|||||
著者所属(日) | ||||||
値 | 奥羽大学歯学部口腔病態解析制御学講座 | |||||
著者所属(英) | ||||||
言語 | en | |||||
値 | Ohu University School of Dentistry, Department of Oral Medical Science | |||||
抄録(英) | ||||||
内容記述タイプ | Other | |||||
内容記述 | The effects of cell components (Ca-m) obtained from Candida albicans on immune response of murine were investigated. Intraperitoneal injection of Ca-m caused a significant increase in direct plaque-forming cell (PFC) numbers in the spleen, and a suppressive effect on delayed hypersensitivity in the footpad 3 days or 5 days after antigenic stimulation with sheep erythrocytes (SRBC), respectively. Injection of Ca-m and SRBC together into congenitally athymic nude mice did not elicit a greater anti-SRBC PFC response than controls without Ca-m. The mice injected with Ca-m at the time of priming SRBC and then immunized with trinitrophenylated SRBC showed a greater anti-trinitrophenyl PFC response than controls without the injection of Ca-m. In vitro proliferative response of T lymphocytes in the peritoneal exudate of C3H/HeN mice immunized with Ca-m and SRBC [T(Ca-m+SRBC)] wsa examined by determining the uptake of tritiated thymidine in to cells. Although the cells from mice which injected with SRBC only [T(SRBC)] showed a basal proliferative response in the absence of antigen, the addition of specific antigen increased the response sharply. However, the basal response of T(Ca-m+SRBC) disappeared. The basal proliferation was seen to be due to or dependent on the proliferation of Ia^+ T cells. The quantity of IL-4, but not IL-2, in the supernatant obtained from cultures containing T(Ca-m+SRBC) and anti-CD3 antibodies was higher than that of T(SRBC) and anti-CD3 antibodies cultures. These results suggest that Ca-m have an adjuvant effect on the humoral antibody response and a suppressive effect on delayed sensitivity reaction on murine immuno system, and these effects are mainly due to the enhanced induction of Th2 cells. | |||||
雑誌書誌ID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN1010214X | |||||
書誌情報 |
奥羽大学歯学誌 巻 31, 号 2, p. 103-112, 発行日 2004-06-30 |