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ラット顎下腺の成長発育におけるIGF-I受容体mRNAの局在
https://ohu-lib.repo.nii.ac.jp/records/2275
https://ohu-lib.repo.nii.ac.jp/records/22757c893dd0-caa7-4e8e-88f3-5c62b81c0879
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KJ00004260480.pdf (1.5 MB)
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| Item type | 紀要論文(ELS)_JAIRO Cloud（WEKO3）対応_596d4a9f(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2004-06-30 | |||||
| タイトル | ||||||
| タイトル | ラット顎下腺の成長発育におけるIGF-I受容体mRNAの局在 | |||||
| タイトル | ||||||
| タイトル | In Situ Localization of mRNA for Insulin-like Growth Factor Receptor Type I in the Developing Rat Submandibular Gland | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | IGF-IR | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | in situ hybridization | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | rat | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | submandibular gland | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| ページ属性 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | P(論文) | |||||
| 記事種別(日) | ||||||
| 値 | 原著論文 | |||||
| 記事種別(英) | ||||||
| 言語 | en | |||||
| 値 | Original Article | |||||
| 著者名(日) |
安部, 仁晴
× 安部, 仁晴× 岡本, 浩史× 中川, 敏浩× 山本, 茂久 |
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| 著者名よみ |
アベ, キミハル
× アベ, キミハル× オカモト, ヒロシ× ナカガワ, トシヒロ× ヤマモト, シゲヒサ |
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| 著者名(英) |
AMBE, Kimiharu
× AMBE, Kimiharu× OKAMOTO, Hiroshi× NAKAGAWA, Toshihiro× YAMAMOTO, Shigehisa |
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| 著者所属(日) | ||||||
| 値 | 奥羽大学歯学部生体構造学講座口腔組織学分野 | |||||
| 著者所属(日) | ||||||
| 値 | 奥羽大学歯学部生体構造学講座口腔組織学分野 | |||||
| 著者所属(日) | ||||||
| 値 | 奥羽大学歯学部生体構造学講座口腔組織学分野 | |||||
| 著者所属(日) | ||||||
| 値 | 奥羽大学歯学部生体構造学講座口腔組織学分野 | |||||
| 著者所属(英) | ||||||
| 言語 | en | |||||
| 値 | Division of Oral Histology, Department of Morphological Biology, Ohu University School of Dentistry | |||||
| 著者所属(英) | ||||||
| 言語 | en | |||||
| 値 | Division of Oral Histology, Department of Morphological Biology, Ohu University School of Dentistry | |||||
| 著者所属(英) | ||||||
| 言語 | en | |||||
| 値 | Division of Oral Histology, Department of Morphological Biology, Ohu University School of Dentistry | |||||
| 著者所属(英) | ||||||
| 言語 | en | |||||
| 値 | Division of Oral Histology, Department of Morphological Biology, Ohu University School of Dentistry | |||||
| 抄録(英) | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Insulin-like growth factor I(IGF-I) stimulates the growth of a variety of cell types in vivo and in vitro, and its plasma concentration is closely regulated by growth hormone. Histochemical studies on the distribution of IGF-I immunoreactivity and IGF-ImRNA in adult and fetal tissues of several species have also shown multiple sites for the synthesis of IGF-I, implying a paracrine/autocrine as well as an endocrine mechanism for the action of this growth factor. In order to clarify the role of IGF in process of morphogenisis, the expression of mRNA for IGF-I receptor (IGF-IR) was investigated in the submandibular gland of developing rats by in situ hybridization technique. The expression of the IGF-IR mRNA signal was observed in the cell of terminal portion and in the duct at newborn. The signal in ductal cell at newborn was stronger than that in the cell of terminal portion. Beside, the signal of IGF-IR mRNA was shown in the endothelial cell around the ductal system. With the differentiation of submandibular gland, the signal of IGF-IR mRNA was shown negatively with aciner cells, however, those signal were observed at undifferentiat cells in acinus. In contrast, although the ductal system was identified as intercalated ducts, striated ducts and excretory ducts at postnatal 21 days, the signal of IGF-IR mRNA had been observed continuously since newborn stage. At postnatal 50 days, the IGF-IR mRNA signal localized exclusively in the granular convoluted tubules and intercalated ducts, but it was not observed in acinus. These results suggest that IGF-IR induces proliferation and growth of cells in early stage of submandibular gland development. In addition, the expression of IGF-IR mRNA signal may have an important role in the differentiation into aciner cells and granular convoluted tubule cells in morphogenisis of the rat submandibular gland. | |||||
| 雑誌書誌ID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN1010214X | |||||
| 書誌情報 |
奥羽大学歯学誌 巻 31, 号 2, p. 113-118, 発行日 2004-06-30 |
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