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破骨細胞分化におけるCyclooxygenase-2選択的阻害剤投与の影響について
https://ohu-lib.repo.nii.ac.jp/records/2281
https://ohu-lib.repo.nii.ac.jp/records/22810952b051-2e8f-4b18-a2ab-4f8c94061ce3
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KJ00004260486.pdf (3.9 MB)
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| Item type | 紀要論文(ELS)_JAIRO Cloud（WEKO3）対応_596d4a9f(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2004-06-30 | |||||
| タイトル | ||||||
| タイトル | 破骨細胞分化におけるCyclooxygenase-2選択的阻害剤投与の影響について | |||||
| タイトル | ||||||
| タイトル | The Effect of Selective Cyclooxygenase-2 Inhibitor in the Osteoclast Differentiation | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | selective COX-2 inhibitor | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | prostaglandins | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | osteoclast differentiation | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| ページ属性 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | P(論文) | |||||
| 記事種別(日) | ||||||
| 値 | 原著論文 | |||||
| 記事種別(英) | ||||||
| 言語 | en | |||||
| 値 | Original Article | |||||
| 著者名(日) |
小板橋, 勉
× 小板橋, 勉 |
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| 著者名よみ |
コイタバシ, ツトム
× コイタバシ, ツトム |
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| 著者名(英) |
KOITABASHI, Tsutomu
× KOITABASHI, Tsutomu |
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| 著者所属(日) | ||||||
| 値 | 奥羽大学大学院歯学研究科顎口腔外科学専攻 | |||||
| 著者所属(英) | ||||||
| 言語 | en | |||||
| 値 | Ohu University Graduate School of Dentistry Oral Surgery Major | |||||
| 抄録(英) | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | When the lateral row of maxillary molars is extracted, non-traumatic and synchronous remodeling sequence is taken place along the buccal surface of the alveolar bone of mandibular antagonist teeth. This event is mediated by a variety of mononuclear cells present in and/or recruited de novo from the blood stream. In this study the author examined the role of prostaglandins in the recruitment of osteoclasts using in vivo experimental model and selective cyclooxygenase-2 (COX-2) inhibitor by histochemistry and immunohistochemistry. Sixty male Wister rats, 7-week-old, were divided into two groups. In the experimental group, rats were fed a standard diet containing 400 ppm Nimesulide beginning a week before tooth extraction. In the control group, rats were fed a standard diet without Nimesulide. All rats were sacrificed and mandibule dissected at 0, 1, 2, 3, 4, 5, 6 days after tooth extraction and fixed in a 4% paraformaldehyde. After demineralization in an EDTA solution at room temperature, serial paraffin sections of horizontal plane were cut and stained histochemically using tartrate resistant acid phosphatase (TRAP) activity and immunohistochemically using monoclonal antibodies against ED-1 and polyclonal antibodies against Factor VIII. Mean numbers of multinucleated osteoclast and nuclei of TRAP and ED-1-positive cells, numbers of Factor VIII-positive vessels, change in percentage of osteoclast nuclei per total numbers of TRAP-positive cell nuclei, area of the resorption pits on the alveolar bone surface were measured. Osteoclasts on day 4, a peak of bone resorption in this model, were smaller in number in the experimental group than in the control group. The increase of both TRAP and ED-1-positive cells quantified by the number of nuclei was significantly suppressed on day 4 in the experimental group, as well. These data suggested that less active osteoclast recruitment was due to suppressed recruitment of osteoclast precursors from the circulation. To examine the tendency for mononuclear precursors to multinuclear osteoclasts, the percentage of multinucleated cell nuclei per total numbers of TRAP-positive cells nuclei was calculated. Data revealed significantly higher rate of multinucleation in the experimental group, suggesting enhanced osteoclast differentiation. The present study suggests that the administration of selective COX-2 inhibitor suppresses the recruitment of osteoclast precursors from the circulation, but promotes osteoclast differentiation and ability of bone resorption. | |||||
| 雑誌書誌ID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN1010214X | |||||
| 書誌情報 |
奥羽大学歯学誌 巻 31, 号 2, p. 157-168, 発行日 2004-06-30 |
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