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卵巣摘出ラットの骨密度に対するスタチン長期投与に関する研究
https://ohu-lib.repo.nii.ac.jp/records/2397
https://ohu-lib.repo.nii.ac.jp/records/239743426375-8205-4042-b52c-f915097a7691
名前 / ファイル | ライセンス | アクション |
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KJ00004193763.pdf (1.0 MB)
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Item type | 紀要論文(ELS)_JAIRO Cloud(WEKO3)対応_596d4a9f(1) | |||||
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公開日 | 2005-06-30 | |||||
タイトル | ||||||
タイトル | 卵巣摘出ラットの骨密度に対するスタチン長期投与に関する研究 | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | statins | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | bone mineral density | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | 17β-estradiol | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | parathyroid hormone | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
ページ属性 | ||||||
内容記述タイプ | Other | |||||
内容記述 | P(論文) | |||||
記事種別(日) | ||||||
値 | 原著論文 | |||||
記事種別(英) | ||||||
言語 | en | |||||
値 | Original Article | |||||
著者名(日) |
寺島, 信一
× 寺島, 信一 |
|||||
著者名よみ |
テラシマ, シンイチ
× テラシマ, シンイチ |
|||||
著者名(英) |
TERASHIMA, Shinichi
× TERASHIMA, Shinichi |
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著者所属(日) | ||||||
値 | 奥羽大学大学院歯学研究科歯内歯周療法学専攻 | |||||
著者所属(英) | ||||||
言語 | en | |||||
値 | Ohu University Graduate School of Dentistry, Endodontics and Periodontics Major | |||||
抄録(英) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Atorvastatin inhibits synthesis of mevalonate in cholesterol biosynthesis pathway. Statins such as atorvastatin stimulate osteoblast differentiation and enhance mineralization in vitro. The present study was undertaken to investigate the in vivo effect of atorvastatin on bone mineral density (BMD) in ovariectomized (OVX) rats. Atorvastatin, vehicle, 17β-estradiol (E_2) and human parathyroid hormone (1-34) (hPTH(l-34)J were subcutaneously injected four times a week for 8-12 weeks in OVX rats. Atorvastatin (2mg/kg) alone did not alter BMD of the mandible and the lumbar vertebra in OVX rats. The combination of atorvastatin (2mg/kg) and E_2 (10μg/kg) during 12week treatment significantly increased BMD of molar region in the mandible and the lumbar vertebra. Concomitant injections of atorvastatin (2mg/kg) with hPTH (1-34) (1μg/kg) for 8 weeks significantly increased BMD of molar region of the mandible and the lumbar vertebra. These findings demonstrate that chronic administration of atorvastatin augments BMD of trabecular bone-rich regions such as molar portion of the mandible and the lumbar vertebra in OVX rats treated with submaximal dose of E_2 and hPTH (1-34). | |||||
雑誌書誌ID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN1010214X | |||||
書誌情報 |
奥羽大学歯学誌 巻 32, 号 2, p. 93-102, 発行日 2005-06-30 |