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キトサンオリゴ糖の静脈内投与がマウス口腔粘膜の創傷治癒に及ぼす影響
https://ohu-lib.repo.nii.ac.jp/records/2579
https://ohu-lib.repo.nii.ac.jp/records/2579f67ecb88-6b62-40cb-bc58-a0a12f9043c0
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KJ00004763125.pdf (2.0 MB)
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| Item type | 紀要論文(ELS)_JAIRO Cloud（WEKO3）対応_596d4a9f(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-12-01 | |||||
| タイトル | ||||||
| タイトル | キトサンオリゴ糖の静脈内投与がマウス口腔粘膜の創傷治癒に及ぼす影響 | |||||
| タイトル | ||||||
| タイトル | Effects of Intravenous Administration of Chitosan Oligosaccharide on the Wound Healing Process of Oral Mucosal Injury in Mice | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | chitin | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | chitosan | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | chitosan oligosaccharide | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | wound healing | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| ページ属性 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | P(論文) | |||||
| 記事種別(日) | ||||||
| 値 | 原著論文 | |||||
| 記事種別(英) | ||||||
| 言語 | en | |||||
| 値 | Original Article | |||||
| 著者名(日) |
千葉, 有
× 千葉, 有× 釜田, 朗× 菅島, 正栄× 田谷, かほる× 松渕, 志帆× 斎藤, 高弘× 浜田, 節男 |
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| 著者名よみ |
チバ, ユウ
× チバ, ユウ× カマダ, アキラ× スガシマ, ショウエイ× タヤ, カホル× マツブチ, シホ× サイトウ, タカヒロ× ハマダ, セツオ |
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| 著者名(英) |
CHIBA, YU
× CHIBA, YU× KAMADA, Akira× SUGASHIMA, Shoei× TAYA, Kahoru× MATSUBUCHI, Shiho× SAITO, Takahiro× HAMADA, Setsuo |
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| 著者所属(日) | ||||||
| 値 | 奥羽大学歯学部口腔病態解析制御学講座歯科薬理学分野 | |||||
| 著者所属(日) | ||||||
| 値 | 奥羽大学歯学部診療科学講座 | |||||
| 著者所属(日) | ||||||
| 値 | 奥羽大学歯学部口腔病態解析制御学講座歯科薬理学分野 | |||||
| 著者所属(日) | ||||||
| 値 | 奥羽大学歯学部口腔病態解析制御学講座歯科薬理学分野 | |||||
| 著者所属(日) | ||||||
| 値 | 奥羽大学歯学部口腔病態解析制御学講座歯科薬理学分野 | |||||
| 著者所属(日) | ||||||
| 値 | 奥羽大学歯学部診療科学講座 | |||||
| 著者所属(日) | ||||||
| 値 | 奥羽大学歯学部口腔病態解析制御学講座歯科薬理学分野 | |||||
| 著者所属(英) | ||||||
| 言語 | en | |||||
| 値 | Department of Oral Medical Science (Division of Dental Pharmacology), Ohu University School of Dentistry | |||||
| 著者所属(英) | ||||||
| 言語 | en | |||||
| 値 | Department of Therapeutic Science, Ohu University School of Dentistry | |||||
| 著者所属(英) | ||||||
| 言語 | en | |||||
| 値 | Department of Oral Medical Science (Division of Dental Pharmacology), Ohu University School of Dentistry | |||||
| 著者所属(英) | ||||||
| 言語 | en | |||||
| 値 | Department of Oral Medical Science (Division of Dental Pharmacology), Ohu University School of Dentistry | |||||
| 著者所属(英) | ||||||
| 言語 | en | |||||
| 値 | Department of Oral Medical Science (Division of Dental Pharmacology), Ohu University School of Dentistry | |||||
| 著者所属(英) | ||||||
| 言語 | en | |||||
| 値 | Department of Therapeutic Science, Ohu University School of Dentistry | |||||
| 著者所属(英) | ||||||
| 言語 | en | |||||
| 値 | Department of Oral Medical Science (Division of Dental Pharmacology), Ohu University School of Dentistry | |||||
| 抄録(英) | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Chitosan is a natural macromolecule obtained by deacetylating chitin in a concentrated alkaline solution. Chitosan is pharmacologically active, having been shown to accelerate wound healing, inhibit tumor growth, and lower serum cholesterol. A low molecular weight from of chitosan, chitosan oligosaccharide, has also been developed, and its pharmacological activities are currently being investigated. However, the pharmacological actions that occur when chitosan oligosaccharide is administered systemically have not been fully elucidated. We previously investigated the effects of oral administration of chitosan oligosaccharide on wound healing of the oral mucosa in vitro and in vivo, and here, we investigated the effects of intravenous administration of chitosan oligosaccharides on healing of oral mucosal injury in mice. An Nd-YAG laser was used to damage the oral mucosa, and then various concentrations of chitosan oligosaccharide were intermittently administered intravenously. As a control, one group of mice under-went the wounding process, but received no chitosan. After a certain period, the damaged oral mucosa was excised, and tissue sections were prepared for morphological observation. When compared to controls, animals treated with chitosan oligosaccharide demonstrated faster resolution of tissue unevenness and new capillary vessel formation, and greater fibroblast induction and subsequent collagen fiber production. Hence, intravenous administration of chitosan oligosaccharide might accelerate wound healing after oral mucosal injury. | |||||
| 雑誌書誌ID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN1010214X | |||||
| 書誌情報 |
奥羽大学歯学誌 巻 33, 号 4, p. 207-213, 発行日 2006-12 |
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