@article{oai:ohu-lib.repo.nii.ac.jp:00002150,
 author = {高橋, 顕仁 and タカハシ, アキヒト and TAKAHASHI, Akihito},
 issue = {2},
 journal = {奥羽大学歯学誌},
 month = {Jun},
 note = {P(論文), Chitinoligosaccharide and chitosanoligosaccharide which are polymers of several N-acetyl-D-glucosamine and D-glucosamine, are water-soluble. The aim of this study was to clarify the pharmacological effects of these oligosaccharides on acute inflammation. The following results were obtained. 1. The inhibitory activity of vascular permeability of tested drugs to ICR-mice was estimated to be in the following order, calculated from 50% effective dose (ED_<50>). Chitosanoligosaccharide > chitinoligosaccharide > aspirin 2. The inhibitory activity of tested drugs to both cyclooxygenase (COX)-1 and 2 was estimated to be in the following order, calculated from 50% inhibitory concentration (IC_<50>). Chitosanoligosaccharide > aspirin > chitinoligosaccharide 3. The selectivity of COX-1 and 2 was estimated to be in the following order, judging from COX-1(IC_<50>)/COX-2(IC_<50>) calculation. Chitinoligosaccharide > chitosanoligosaccharide > aspirin 4. The analgesic activity for acute inflammatory pain was estimated to be in the following order, calculated from ED_<50>. Chitinoligosaccharide > chitosanoligosaccharide > aspirin 5. It was seemed that anti-inflammatory effects of chitosanoligosaccharide on mice gingivae was more than aspirin. Based on these pharmacological findings, it was clarified that chitinoligosaccharide had greater analgesic activity and fewer side effects, based on the inhibited COX-1, than the other tested drugs, and chitosanoligosaccharide had greater inhibitory activity of vascular permeability and greater inhibitory activity of COX-2, based on causing inflammation, than the other tested drugs.},
 pages = {115--126},
 title = {炎症に対するキチンオリゴ糖およびキトサンオリゴ糖の薬理学的検討},
 volume = {30},
 year = {2003}
}