{"created":"2023-05-15T14:18:45.362610+00:00","id":2231,"links":{},"metadata":{"_buckets":{"deposit":"c7e04884-1f4f-4d5e-b6ea-00f62f623bfd"},"_deposit":{"created_by":3,"id":"2231","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2231"},"status":"published"},"_oai":{"id":"oai:ohu-lib.repo.nii.ac.jp:00002231","sets":["90:96:97"]},"author_link":["8281","8279","8280"],"item_1_biblio_info_14":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2004-03-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"22","bibliographicPageStart":"7","bibliographicVolumeNumber":"31","bibliographic_titles":[{"bibliographic_title":"奥羽大学歯学誌"}]}]},"item_1_creator_6":{"attribute_name":"著者名(日)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"前田, 豊信"}],"nameIdentifiers":[{"nameIdentifier":"8279","nameIdentifierScheme":"WEKO"}]}]},"item_1_creator_7":{"attribute_name":"著者名よみ","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"マエダ, トヨノブ"}],"nameIdentifiers":[{"nameIdentifier":"8280","nameIdentifierScheme":"WEKO"}]}]},"item_1_creator_8":{"attribute_name":"著者名(英)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"MAEDA, Toyonobu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"8281","nameIdentifierScheme":"WEKO"}]}]},"item_1_description_1":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_type":"Other"}]},"item_1_description_12":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"The cholesterol-lowering drugs statins, including simvastatin, cerivastatin and atorvastatin, are pro-drug of a potent 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors and inhibit cholesterol synthesis in humans and animals. Simvastatin at 10^<-7> M markedly increased mRNA expression of BMP-2, VEGF, alkaline phosphatase, type I collagen, bone sialoprotein, and osteocalcin (OCN) in MC3T3-E1 cells, and clearly suppressed gene expression of matrix metalloproteinase (MMP)-1 and MMP-13. Extracellular accumulation of proteins such as VEGF, OCN, collagenase-digestive proteins, and noncollagenous proteins, was elevated in MC3T3-E1 cells treated with 10^<-7> M simvastatin, and 10^<-8> M cerivastatin. MC3T3-E1 cells stimulated mineralization by treatment of statins, and pretreating these cells with mevalonate, or geranylgeranyl pyrophosphate, mevalonate metabolite, abolished statin induced mineralization. The results indicated that statins stimulate osteoblast differentiation in vitro, and suggest that statins will become useful drugs for the treatment of osteoporosis in the future.","subitem_description_type":"Other"}]},"item_1_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AN1010214X","subitem_source_identifier_type":"NCID"}]},"item_1_text_10":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Ohu University Graduate School of Dentistry, Oral Biochemistry Major"}]},"item_1_text_2":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_text_value":"原著論文"}]},"item_1_text_3":{"attribute_name":"記事種別(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Original Article"}]},"item_1_text_9":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"奥羽大学大学院歯学研究科口腔生化学専攻"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2004-03-31"}],"displaytype":"detail","filename":"KJ00004260436.pdf","filesize":[{"value":"1.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"url":"https://ohu-lib.repo.nii.ac.jp/record/2231/files/KJ00004260436.pdf"},"version_id":"38498bf4-9b98-4523-a3f3-fe832fda7351"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"statins","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"osteoblast","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"differentiation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"mineralization","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"コレステロール合成阻害剤(スタチン)による骨芽細胞分化制御に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"コレステロール合成阻害剤(スタチン)による骨芽細胞分化制御に関する研究"},{"subitem_title":"Study on Regulation of Osteoblastic Differentiation by an Inhibitor of Cholesterol Synthesis (Statin).","subitem_title_language":"en"}]},"item_type_id":"1","owner":"3","path":["97"],"pubdate":{"attribute_name":"公開日","attribute_value":"2004-03-31"},"publish_date":"2004-03-31","publish_status":"0","recid":"2231","relation_version_is_last":true,"title":["コレステロール合成阻害剤(スタチン)による骨芽細胞分化制御に関する研究"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-05-15T14:54:14.168333+00:00"}