{"created":"2023-05-15T14:18:45.409117+00:00","id":2232,"links":{},"metadata":{"_buckets":{"deposit":"e2333a4f-f660-47a2-bc9a-e4693b479c95"},"_deposit":{"created_by":3,"id":"2232","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2232"},"status":"published"},"_oai":{"id":"oai:ohu-lib.repo.nii.ac.jp:00002232","sets":["90:96:97"]},"author_link":["8287","8292","8296","8298","8289","8288","8283","8284","8282","8293","8299","8290","8297","8285","8286","8295","8291","8294"],"item_1_biblio_info_14":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2004-03-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"32","bibliographicPageStart":"23","bibliographicVolumeNumber":"31","bibliographic_titles":[{"bibliographic_title":"奥羽大学歯学誌"}]}]},"item_1_creator_6":{"attribute_name":"著者名(日)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"千葉, 有"}],"nameIdentifiers":[{"nameIdentifier":"8282","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"釜田, 朗"}],"nameIdentifiers":[{"nameIdentifier":"8283","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松渕, 志帆"}],"nameIdentifiers":[{"nameIdentifier":"8284","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田谷, かほる"}],"nameIdentifiers":[{"nameIdentifier":"8285","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"齋藤, 高弘"}],"nameIdentifiers":[{"nameIdentifier":"8286","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"五十嵐, 治義"}],"nameIdentifiers":[{"nameIdentifier":"8287","nameIdentifierScheme":"WEKO"}]}]},"item_1_creator_7":{"attribute_name":"著者名よみ","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"チバ, ユウ"}],"nameIdentifiers":[{"nameIdentifier":"8288","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"カマダ, アキラ"}],"nameIdentifiers":[{"nameIdentifier":"8289","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"マツブチ, シホ"}],"nameIdentifiers":[{"nameIdentifier":"8290","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"タヤ, カホル"}],"nameIdentifiers":[{"nameIdentifier":"8291","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"サイトウ, タカヒロ"}],"nameIdentifiers":[{"nameIdentifier":"8292","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"イガラシ, ハルヨシ"}],"nameIdentifiers":[{"nameIdentifier":"8293","nameIdentifierScheme":"WEKO"}]}]},"item_1_creator_8":{"attribute_name":"著者名(英)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"CHIBA, Yu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"8294","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"KAMADA, Akira","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"8295","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"MATSUBUCHI, Shiho","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"8296","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"TAYA, Kahoru","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"8297","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"SAITO, Takahiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"8298","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"IGARASHI, Haruyoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"8299","nameIdentifierScheme":"WEKO"}]}]},"item_1_description_1":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_type":"Other"}]},"item_1_description_12":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"Chitosan is a natural macromolecule that can be obtained by deacetylation of chitin in concentrated alkaline solution, and it has been known to exhibit various pharmacological actions, including facilitative effects on wound healing. Chitooligosaccharides are oligosaccharides composed of two to seven glucosamine residues, which are the basic molecules of chitosan. Systemic administration of chitooligosaccharides facilitates wound healing, but its mechanism remains largely unknown. The present study was investigated the effects of systemic administration of chitooligosaccharides on healing of the oral mucous membrane in vitro and in vivo. Human gingiva-derived fibroblast were incubated with 0.25-1.0% of chitooligosaccharides, and the cell number was counted after 24, 48, 72, 96, 120 and 144 hours. In addition, to determine whether systemic administration of chitooligosaccharides facilitates healing of mouse oral mucous membrane damaged by neodymium YAG laser irradiation, the oral mucous membrane was sampled at certain times after laser irradiation and was analyzed histologically. The results were as follows: 1. With 0.5-0.75% of chitooligosaccharides, the number of fibroblasts increased during the early stages of incubation, but with high concentrations of chitooligosaccharides, the number of fibroblast decreased. 2. Systemic administration of chitooligosaccharides facilitated proliferation of fibroblast, while continuous high-dose administration suppressed proliferation. The above findings clarify that chitooligosaccharides facilitate the proliferation of fibroblast in vitro and that systemic administration facilitates wound healing in vivo. In addition, there appear to be optimal doses in both in vitro and in vivo applications.","subitem_description_type":"Other"}]},"item_1_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AN1010214X","subitem_source_identifier_type":"NCID"}]},"item_1_text_10":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Dental Pharmacology, Ohu University School of Dentistry"},{"subitem_text_language":"en","subitem_text_value":"Department of Therapeutic Science, Ohu University School of Dentistry"},{"subitem_text_language":"en","subitem_text_value":"Department of Dental Pharmacology, Ohu University School of Dentistry"},{"subitem_text_language":"en","subitem_text_value":"Department of Dental Pharmacology, Ohu University School of Dentistry"},{"subitem_text_language":"en","subitem_text_value":"Department of Therapeutic Science, Ohu University School of Dentistry"},{"subitem_text_language":"en","subitem_text_value":"Department of Dental Pharmacology, Ohu University School of Dentistry"}]},"item_1_text_2":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_text_value":"原著論文"}]},"item_1_text_3":{"attribute_name":"記事種別(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Original Article"}]},"item_1_text_9":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"奥羽大学歯学部歯科薬理学講座"},{"subitem_text_value":"奥羽大学歯学部診療科学講座"},{"subitem_text_value":"奥羽大学歯学部歯科薬理学講座"},{"subitem_text_value":"奥羽大学歯学部歯科薬理学講座"},{"subitem_text_value":"奥羽大学歯学部診療科学講座"},{"subitem_text_value":"奥羽大学歯学部歯科薬理学講座"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2004-03-31"}],"displaytype":"detail","filename":"KJ00004260437.pdf","filesize":[{"value":"2.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"url":"https://ohu-lib.repo.nii.ac.jp/record/2232/files/KJ00004260437.pdf"},"version_id":"cbb9edaa-2b27-415d-a9af-2f965d645b1a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"chitin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"chitosan","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"chitooligosaccharides","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"wound healing","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"fibroblast","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"キトサンオリゴ糖の創傷治癒促進作用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"キトサンオリゴ糖の創傷治癒促進作用"},{"subitem_title":"Facilitative Effects of Chitooligosaccharides on Wound Healing","subitem_title_language":"en"}]},"item_type_id":"1","owner":"3","path":["97"],"pubdate":{"attribute_name":"公開日","attribute_value":"2004-03-31"},"publish_date":"2004-03-31","publish_status":"0","recid":"2232","relation_version_is_last":true,"title":["キトサンオリゴ糖の創傷治癒促進作用"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-05-15T14:54:14.919808+00:00"}