@article{oai:ohu-lib.repo.nii.ac.jp:00002488, author = {伊東, 博司 and 奥山, 典子 and 阿部, 匡聡 and 櫻井, 裕子 and 遊佐, 淳子 and 堀内, 登 and 山崎, 章 and イトウ, ヒロシ and オクヤマ, ノリコ and アベ, マサトシ and サクライ, ユウコ and ユサ, ジュンコ and ホリウチ, ノボル and ヤマサキ, アキラ and ITO, Hiroshi and OKUYAMA, Noriko and ABE, Masatoshi and SAKURAI, Yuuko and YUSA, Junko and HORIUCHI, Noboru and YAMASAKI, Akira}, issue = {1}, journal = {奥羽大学歯学誌}, month = {Mar}, note = {P(論文), 4-nitroquinoline N-oxide (4NQO) administrated rats have high occurrence of palatal squamous cell carcinoma (SCO, which almost always accompanies resorption of the jaw bone. We have developed a cell strain (11/8F) from a rat palatal SCC induced by 4NQO administration. The cultured cells are polygonal or round in shape, and they exhibited cobble-stone growth pattern. Immunocytochemically, 11/8F cells were positive with four anti-cytokeratin antibodies; AE1, AE3, CAM5.2, and KL1. It is also found that an immunoreactivity for parathyroid hormone-related protein (PTHrP), which is closely related to cancerous bone resorption. In addition, expression of PTHrP mRNA were identified. The cell strain 11/8F, exhibiting characters as noted above, might permit establshing an experimental model to clarify mechanisms of bone destruction with oral SCC invasion.}, pages = {49--55}, title = {ラット口蓋癌由来培養細胞の生物学的性状解明}, volume = {33}, year = {2006} }