@article{oai:ohu-lib.repo.nii.ac.jp:00002745,
 author = {田中, 三千三郎 and 安部, 仁晴 and 中川, 敏浩 and タナカ, ミチサブロウ and アベ, キミハル and ナカガワ, トシハル and TANAKA, Michisaburoh and AMBE, Kimiharu and NAKAGAWA, Toshihiro},
 issue = {1},
 journal = {奥羽大学歯学誌},
 month = {Jan},
 note = {P(論文), In order to clarify the role of growth factors in developing lingual papillae, the expression of TGF-β receptor (TGFβR), Flt-1, KDR/Flk-1 and low affinity NGF receptor (LNGFR) were investigated on the human circumvallate papillae using an immunohistochemical method. At fetal 16 weeks, immunoreactivity of TGFβR was detected on many cells at epithelial and mesenchymal tissue in the circumvallate papillae. Immunoreactivity of TGFRR weakened gradually in developing circumvallate papillae, and was restricted only to epithelial tissue at fetal 28 weeks. Immunoreactivity of Flt-1 was similar to that of KDR/Flk-1, which was expressed in endothelial cells, epithelial cells and mesenchymal tissue. Those expressions were intensive at surface of circumvallate papillae. However, immunoreactivity of Flt-1 and KDR/Flk-1 was localized at microvascular endothelial cells in fetal 28 weeks. Immunoreactivity of LNGFR was expressed in mesenchymal tissue on basal papillae at fetal 16 weeks. On the other hand, immunoreaction of LNGFR at fetal 21 weeks was extended to surface of circumvallate papillae, which was localized at nerve fibers at fetal 28 weeks. With regard to the immunolocalization of each antibody in taste buds, the expression of TGFβR was observed at all cells, those of Flt-1 and KDR/Flk-1 were visible at a few cells in taste buds. These results suggest that TGFβR, Flt-1, KDR/Flk-1 and LNGFR are concerned with the morphogenesis of circumvallate papillae. In addition, TGFβR, KDR/Flk-1 and Flt-1 may play an important role in the differentiation of taste buds.},
 pages = {13--24},
 title = {有郭乳頭の形態形成における細胞増殖因子受容体の発現},
 volume = {35},
 year = {2008}
}