{"created":"2023-05-15T14:19:22.631010+00:00","id":3451,"links":{},"metadata":{"_buckets":{"deposit":"2dda5a52-3dae-453d-9fcf-6bd818ced0b2"},"_deposit":{"created_by":3,"id":"3451","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3451"},"status":"published"},"_oai":{"id":"oai:ohu-lib.repo.nii.ac.jp:00003451","sets":["90:210:213"]},"author_link":["11791"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2号","bibliographicPageStart":"61-76","bibliographicVolumeNumber":"36巻","bibliographic_titles":[{"bibliographic_title":"奥羽大学歯学誌"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ラットを用いた片側性の臼歯喪失が下顎頭軟骨に及ぼす影響を細胞レベルで検討した。実験的な片側臼歯抜歯を行い、軟骨細胞の増殖及び分化マーカーを用いた免疫組織化学染色により下顎頭軟骨を形態学的に検索した。抜歯側ではIhh、PTHrP、およびSox9の発現が減少した結果、細胞の分化、増殖が抑制され、これと関連して軟骨基質であるアグリカン、type II collagen、およびtype X collagenが減少した。非抜歯側では、Ihh、PTHrP、およびSox9の発現が増加した結果、細胞の分化、増殖が促進し、これと関連して軟骨基質であるアグリカン、type II collagen、およびtype X collagenが増加した。片側臼歯の抜歯によって引き起こされた機械的負荷の変化はIhh、PTHrP、Sox9といった成長因子が関与し、顎関節の軟骨代謝に影響を及ぼす可能性が示唆された。","subitem_description_type":"Abstract"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0916-2313","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"高橋, 一人"}],"nameIdentifiers":[{"nameIdentifier":"11791","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2014-04-14"}],"displaytype":"detail","filename":"S36(2)61-76.pdf","filesize":[{"value":"3.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"S36(2)61-76.pdf","url":"https://ohu-lib.repo.nii.ac.jp/record/3451/files/S36(2)61-76.pdf"},"version_id":"5e122192-e106-43f5-80f3-1e4134c9c074"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Alcian Blue; Broxuridine; 細胞計数; 細胞分化; *軟骨(病理学); *抜歯; 免疫組織化学; Proliferating Cell Nuclear Antigen; Sprague-Dawleyラット; 軟骨細胞; *臼歯(外科的療法); 細胞増殖; 上皮小体ホルモン関連蛋白質; Collagen Type II; Collagen Type X; SOX9転写因子; Hedgehog Proteins","subitem_subject_scheme":"Other"},{"subitem_subject":"*Meckel軟骨(病理学)","subitem_subject_scheme":"Other"},{"subitem_subject":"ラット; 動物; メス; 歯学","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ラット片側臼歯喪失に対する下顎頭軟骨の組織化学的検索","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ラット片側臼歯喪失に対する下顎頭軟骨の組織化学的検索"}]},"item_type_id":"10002","owner":"3","path":["213"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-04-14"},"publish_date":"2014-04-14","publish_status":"0","recid":"3451","relation_version_is_last":true,"title":["ラット片側臼歯喪失に対する下顎頭軟骨の組織化学的検索"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-05-15T14:43:13.353437+00:00"}