{"created":"2023-05-15T14:19:24.019035+00:00","id":3482,"links":{},"metadata":{"_buckets":{"deposit":"e65f9220-51dd-4127-9f36-559777ab4d9c"},"_deposit":{"created_by":3,"id":"3482","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3482"},"status":"published"},"_oai":{"id":"oai:ohu-lib.repo.nii.ac.jp:00003482","sets":["90:210:215"]},"author_link":["11880","11879"],"item_10002_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"プロテアソーム阻害剤エポキソマイシンとMG262はヒト口腔扁平上皮癌細胞(HSC-3)によるウロキナーゼ型プラスミノーゲンアクチベータ発現を抑制する"}]},"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4号","bibliographicPageStart":"139-147","bibliographicVolumeNumber":"36巻","bibliographic_titles":[{"bibliographic_title":"奥羽大学歯学誌"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"プロテアソーム阻害剤のエポキソマイシンとMG262が、HSC-3細胞におけるウロキナーゼ型プラスミノーゲンアクチベータ(uPA)のmRNA発現とuPA産生に及ぼす影響について検討した。エポキソマイシンとMG262はuPA mRNA発現とuPA産生を用量依存性に抑制した。経時変化の検討では、エポキソマイシンまたはMG262への曝露から6時間程度で、uPA mRNA発現に顕著な減少が認められ、抑制効果は12および24時間後と同等またはやや強かった。エポキソマイシンとMG262は核性因子(NF)-κB-依存性プロモーターの転写活性を弱めた。uPA遺伝子の転写はNF-κB活性に依存することが知られており、これらのプロテアソーム阻害剤によるuPA遺伝子発現の抑制は、構成的NF-κB活性阻害の影響と考えられる。またエポキソマイシンとPG262はHSC-3細胞の浸潤活性を低下させた。プロテアソーム阻害剤による浸潤活性の減少はuPA産生抑制の影響を一部に受けていると考えられた。","subitem_description_type":"Abstract"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0916-2313","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Abe, Masatoshi"}],"nameIdentifiers":[{"nameIdentifier":"11879","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Horiuchi, Noboru"}],"nameIdentifiers":[{"nameIdentifier":"11880","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2014-05-13"}],"displaytype":"detail","filename":"S36(4)139-147.pdf","filesize":[{"value":"2.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"S36(4)139-147.pdf","url":"https://ohu-lib.repo.nii.ac.jp/record/3482/files/S36(4)139-147.pdf"},"version_id":"fde2a762-9e7d-4dc9-b151-22c36aeb3d20"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"*Boronic Acids(薬理学); NF-Kappa B; *Oligopeptides(薬理学); Protease Inhibitors(薬理学); mRNA; *U-Plasminogen Activator; 遺伝子発現; *口腔腫瘍(実験的); *扁平上皮癌(実験的); 薬物用量反応関係; ノーザンブロッティング; 腫瘍細胞系","subitem_subject_scheme":"Other"},{"subitem_subject":"*Epoxomicin(薬理学); Proteasome Inhibitors(薬理学); *MG-262(薬理学)","subitem_subject_scheme":"Other"},{"subitem_subject":"ヒト; 歯学","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"The Proteasome Inhibitors Epoxomicin and MG262 Suppress Urokinase-Type Plasminogen Activator Expression by Human Oral Squamous Carcinoma Cells (HSC-3)","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The Proteasome Inhibitors Epoxomicin and MG262 Suppress Urokinase-Type Plasminogen Activator Expression by Human Oral Squamous Carcinoma Cells (HSC-3)","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"3","path":["215"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-05-13"},"publish_date":"2014-05-13","publish_status":"0","recid":"3482","relation_version_is_last":true,"title":["The Proteasome Inhibitors Epoxomicin and MG262 Suppress Urokinase-Type Plasminogen Activator Expression by Human Oral Squamous Carcinoma Cells (HSC-3)"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-05-15T18:27:56.070709+00:00"}