{"created":"2023-05-15T14:19:30.100127+00:00","id":3593,"links":{},"metadata":{"_buckets":{"deposit":"fa7bbfb8-ed1b-4ec3-9cef-fce03fd8edd1"},"_deposit":{"created_by":3,"id":"3593","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3593"},"status":"published"},"_oai":{"id":"oai:ohu-lib.repo.nii.ac.jp:00003593","sets":["90:217:221"]},"author_link":["12267","12266","12265"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4号","bibliographicPageStart":"161-171","bibliographicVolumeNumber":"37巻","bibliographic_titles":[{"bibliographic_title":"奥羽大学歯学誌"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ヒト口腔扁平上皮癌細胞HSC-3を用い、上皮細胞におけるHsp47の発現とIV型コラーゲン産生との関係、および扁平上皮癌細胞における浸潤、転移との関係を検討した。各増殖段階でのHsp47発現とIV型コラーゲン産生との関係を検討した。Hsp47の発現は増殖期からconfluent期にかけて増加したが、confluent期以降は有意に減少した。IV型コラーゲンも同様の発現パターンを示した。また、蛍光二重染色ではHsp47とIV型コラーゲンが核周囲の領域で共発現し、両者の結合が示唆された。以上の結果から、上皮細胞においてHsp47はIV型コラーゲンの産生を介助することで細胞移動に必要な基底膜産生に関与していることが示唆され、confluent期以降の両者の減少が腫瘍細胞としての運動性の確保に関与しているとの可能性が考えられた。","subitem_description_type":"Abstract"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0916-2313","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"奥山, 典子"}],"nameIdentifiers":[{"nameIdentifier":"12265","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"遊佐, 淳子"}],"nameIdentifiers":[{"nameIdentifier":"12266","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊東, 博司"}],"nameIdentifiers":[{"nameIdentifier":"12267","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2014-05-22"}],"displaytype":"detail","filename":"S37(4)161-171.pdf","filesize":[{"value":"1.8 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"S37(4)161-171.pdf","url":"https://ohu-lib.repo.nii.ac.jp/record/3593/files/S37(4)161-171.pdf"},"version_id":"aa00bcf4-ac8a-4ac1-8f81-0b0610ac838f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"細胞接着分子; mRNA; 角化細胞; 基底膜; 蛍光; *口腔腫瘍(実験的); 染色; 培養細胞; *扁平上皮癌(実験的); ウエスタンブロッティング; RT-PCR法; 細胞増殖; Collagen Type I; Collagen Type III; Collagen Type XVIII; Collagen Type IV; *HSP47 Heat-Shock Proteins","subitem_subject_scheme":"Other"},{"subitem_subject":"Kalinin","subitem_subject_scheme":"Other"},{"subitem_subject":"ヒト; 歯学","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ヒト口腔扁平上皮癌細胞HSC-3におけるHsp47の発現","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ヒト口腔扁平上皮癌細胞HSC-3におけるHsp47の発現"}]},"item_type_id":"10002","owner":"3","path":["221"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-05-22"},"publish_date":"2014-05-22","publish_status":"0","recid":"3593","relation_version_is_last":true,"title":["ヒト口腔扁平上皮癌細胞HSC-3におけるHsp47の発現"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-05-15T18:18:36.834838+00:00"}