{"created":"2023-05-15T14:19:41.037766+00:00","id":3812,"links":{},"metadata":{"_buckets":{"deposit":"0bdf2a70-c3bb-42cb-9d06-3bf1d6509992"},"_deposit":{"created_by":3,"id":"3812","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3812"},"status":"published"},"_oai":{"id":"oai:ohu-lib.repo.nii.ac.jp:00003812","sets":["90:231:234"]},"author_link":["12948","12950","12949"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2号","bibliographicPageStart":"87-94","bibliographicVolumeNumber":"39巻","bibliographic_titles":[{"bibliographic_title":"奥羽大学歯学誌"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"歯周病原性細菌の一種でヒトの口腔内に多く存在するFusobacterium nucleatumに対するヒト歯肉線維芽細胞の宿主応答に及ぼすアンフォテリシンB(AMPH)の影響を炎症性サイトカインの産生に焦点を当てて解明することを試みた。F.nucleatumの刺激により歯肉線維芽細胞からの産生が認められたIL-6、IL-8、単球走化性タンパク質-1(MCP-1)の中で、MCP-1のみがAMPHにより産生が抑制された。AMPHのIL-6とMCP-1産生に対する相反する作用は線維芽細胞の持つsmad3を活性化するためと考えられる。IL-6、IL-8、MCP-1を検出した同一の培養液を調べてもIL-1β、TNF-α、γ-IFNのような典型的な炎症性サイトカインは検出されなかった。したがって、AMPHが歯肉線維芽細胞の限定的なサイトカイン産生を更に増強もしくは抑制することで、細菌感染に伴う炎症反応を一定の方向に誘導すると考えられた。","subitem_description_type":"Abstract"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0916-2313","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"小林, 良誌"}],"nameIdentifiers":[{"nameIdentifier":"12948","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"玉井, 利代子"}],"nameIdentifiers":[{"nameIdentifier":"12949","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"清浦, 有祐"}],"nameIdentifiers":[{"nameIdentifier":"12950","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2014-09-12"}],"displaytype":"detail","filename":"S39(2)87-94.pdf","filesize":[{"value":"1.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"S39(2)87-94.pdf","url":"https://ohu-lib.repo.nii.ac.jp/record/3812/files/S39(2)87-94.pdf"},"version_id":"78584025-4aed-4566-93f7-307c29cb4a04"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"*Amphotericin B(治療的利用); Interleukin 6; Interleukin 8; 炎症; *歯肉; *線維芽細胞; Chemokine CCL2","subitem_subject_scheme":"Other"},{"subitem_subject_scheme":"Other"},{"subitem_subject":"ヒト; 歯学","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ヒト歯肉線維芽細胞からの炎症性サイトカイン産生に対するamphotericinBの修飾作用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ヒト歯肉線維芽細胞からの炎症性サイトカイン産生に対するamphotericinBの修飾作用"}]},"item_type_id":"10002","owner":"3","path":["234"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-09-12"},"publish_date":"2014-09-12","publish_status":"0","recid":"3812","relation_version_is_last":true,"title":["ヒト歯肉線維芽細胞からの炎症性サイトカイン産生に対するamphotericinBの修飾作用"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-05-15T17:53:55.167030+00:00"}