{"created":"2023-05-15T14:19:42.950641+00:00","id":3853,"links":{},"metadata":{"_buckets":{"deposit":"d8e2aa5e-49d1-47ab-aa8f-84a6fb41aa74"},"_deposit":{"created_by":3,"id":"3853","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3853"},"status":"published"},"_oai":{"id":"oai:ohu-lib.repo.nii.ac.jp:00003853","sets":["90:231:239"]},"author_link":["13086","13087","13085","13088"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4号","bibliographicPageStart":"219-226","bibliographicVolumeNumber":"39巻","bibliographic_titles":[{"bibliographic_title":"奥羽大学歯学誌"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ヒト骨芽細胞様骨肉腫細胞(SaOS2)を用い、ストレス要因である培養環境pHの影響について検討した。pHの上昇に伴ってSaOS2のアルカリフォスファターゼ活性は上昇し、DNA合成能は低下した。real time PCRとELISAで検討したTGF-β1産生は、コントロールを1とした時のmRNA発現が培養3時間ではpH7.8で3.0倍、6時間ではpH7.6で3.6倍と促進され、培養上清中の産生も有意に増加した。IL-11mRNAの発現も培養3時間ではpH7.8で3.8倍、6時間ではpH7.6で5.9倍と促進された。産生されたIL-11mRNAは抗TGF-β1抗体の添加により有意に発現が抑制され、NFκB阻害剤であるPDTCはpH7.6において濃度依存的にTGF-β1mRNAの発現を有意に抑制した。pHの変化により活性化されたNF-κBのシグナルはTGF-β産生促進に働くが、そのオートクリンの結果産生されたIL-11がNF-κBの活性を抑制するというネガティブフィードバックの存在が示唆された。","subitem_description_type":"Abstract"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0916-2313","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"黒田, 栄子"}],"nameIdentifiers":[{"nameIdentifier":"13085","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"廣瀬, 公治"}],"nameIdentifiers":[{"nameIdentifier":"13086","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐藤, 直生"}],"nameIdentifiers":[{"nameIdentifier":"13087","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"福井, 和徳"}],"nameIdentifiers":[{"nameIdentifier":"13088","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2014-10-16"}],"displaytype":"detail","filename":"S39(4)219-226.pdf","filesize":[{"value":"1.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"S39(4)219-226.pdf","url":"https://ohu-lib.repo.nii.ac.jp/record/3853/files/S39(4)219-226.pdf"},"version_id":"5b2c147c-6520-4909-bdeb-bc01ed1e14b0"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Alkaline Phosphatase; *Cytokines; DNA; Interleukin 11; Pyrrolidines; mRNA; Thiocarbamates; *骨芽細胞; 骨肉腫(実験的); *水素イオン濃度; 培養細胞; Transforming Growth Factor Beta1","subitem_subject_scheme":"Other"},{"subitem_subject":"Pyrrolidine Dithiocarbamic Acid","subitem_subject_scheme":"Other"},{"subitem_subject":"ヒト; 歯学","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"培養環境pHがおよぼす骨芽細胞のサイトカイン産生についての研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"培養環境pHがおよぼす骨芽細胞のサイトカイン産生についての研究"}]},"item_type_id":"10002","owner":"3","path":["239"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-10-16"},"publish_date":"2014-10-16","publish_status":"0","recid":"3853","relation_version_is_last":true,"title":["培養環境pHがおよぼす骨芽細胞のサイトカイン産生についての研究"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-05-15T15:31:12.687490+00:00"}