{"created":"2023-05-15T14:19:52.088227+00:00","id":4042,"links":{},"metadata":{"_buckets":{"deposit":"2c8b0c44-ba0e-4234-8519-d3b5f12bcbc6"},"_deposit":{"created_by":3,"id":"4042","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"4042"},"status":"published"},"_oai":{"id":"oai:ohu-lib.repo.nii.ac.jp:00004042","sets":["90:246:255"]},"author_link":["13526","13527"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3-4号","bibliographicPageStart":"107-114","bibliographicVolumeNumber":"41巻","bibliographic_titles":[{"bibliographic_title":"奥羽大学歯学誌"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ニコチンによるマクロファージからの炎症性サイトカイン産生促進機能について検討した。U937細胞にP.gingivalis(Pg)由来LPSのみを添加して培養した場合と比べPg由来LPSと二コチンの両方を添加した場合は、pro-IL-1β mRNAの発現がニコチンの濃度依存的に促進され、その濃度が10^-3Mで最大となった。Pg由来LPSと10^-3Mニコチンの併用効果が認められる培養時間は2～4時間であった。U937細胞におけるIL-1β、NLRP3およびcaspase-1いずれの産生量も、Pg由来LPSのみを添加した時と比べ、Pg由来LPSとニコチンを併用添加した時に、その産生が増加した。さらに、NLRP3においては、ニコチン単独添加においてもその産生の促進が認められた。","subitem_description_type":"Abstract"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0916-2313","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"沼田, 匠"}],"nameIdentifiers":[{"nameIdentifier":"13526","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"廣瀬, 公治"}],"nameIdentifiers":[{"nameIdentifier":"13527","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-05-28"}],"displaytype":"detail","filename":"S41(3-4)107-114.pdf","filesize":[{"value":"1.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"S41(3-4)107-114.pdf","url":"https://ohu-lib.repo.nii.ac.jp/record/4042/files/S41(3-4)107-114.pdf"},"version_id":"77e24902-0377-470e-b55a-dc63bf864a87"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Carrier Proteins; *Cytokines; Lipopolysaccharides; *Nicotine; 培養細胞; *マクロファージ; ウエスタンブロッティング; Porphyromonas gingivalis; Caspase 1; RT-PCR法; Interleukin 1 Beta","subitem_subject_scheme":"Other"},{"subitem_subject":"NLRP3 Protein","subitem_subject_scheme":"Other"},{"subitem_subject":"ヒト; 歯学","subitem_subject_scheme":"Other"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ニコチンによるマクロファージからの炎症性サイトカイン産生促進機構の検索","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ニコチンによるマクロファージからの炎症性サイトカイン産生促進機構の検索"}]},"item_type_id":"10002","owner":"3","path":["255"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-05-28"},"publish_date":"2016-05-28","publish_status":"0","recid":"4042","relation_version_is_last":true,"title":["ニコチンによるマクロファージからの炎症性サイトカイン産生促進機構の検索"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-05-15T14:59:51.514904+00:00"}