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炎症に対するキチンオリゴ糖およびキトサンオリゴ糖の薬理学的検討
https://ohu-lib.repo.nii.ac.jp/records/2150
https://ohu-lib.repo.nii.ac.jp/records/2150715ea74d-3da7-4a56-ae65-28e2f6bf1ae7
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KJ00000731673.pdf (1.4 MB)
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| Item type | 紀要論文(ELS)_JAIRO Cloud（WEKO3）対応_596d4a9f(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2003-06-30 | |||||
| タイトル | ||||||
| タイトル | 炎症に対するキチンオリゴ糖およびキトサンオリゴ糖の薬理学的検討 | |||||
| タイトル | ||||||
| タイトル | Study of Pharmacological Effects of Chitinoligosaccharide and Chitosanoligosaccharide on Acute Inflammation | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | chitinoligosaccharide | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | chitosanoligosaccharide | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | vascular permeability | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | inhibitory activity of cyclooxygenase | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | analgesic activity | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| ページ属性 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | P(論文) | |||||
| 記事種別(日) | ||||||
| 値 | 原著論文 | |||||
| 記事種別(英) | ||||||
| 言語 | en | |||||
| 値 | Original Article | |||||
| 著者名(日) |
高橋, 顕仁
× 高橋, 顕仁 |
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| 著者名よみ |
タカハシ, アキヒト
× タカハシ, アキヒト |
|||||
| 著者名(英) |
TAKAHASHI, Akihito
× TAKAHASHI, Akihito |
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| 著者所属(日) | ||||||
| 値 | 奥羽大学歯学部歯科薬理学講座 | |||||
| 著者所属(英) | ||||||
| 言語 | en | |||||
| 値 | Department of Dental Pharmacology, Ohu University School of Dentistry | |||||
| 抄録(英) | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Chitinoligosaccharide and chitosanoligosaccharide which are polymers of several N-acetyl-D-glucosamine and D-glucosamine, are water-soluble. The aim of this study was to clarify the pharmacological effects of these oligosaccharides on acute inflammation. The following results were obtained. 1. The inhibitory activity of vascular permeability of tested drugs to ICR-mice was estimated to be in the following order, calculated from 50% effective dose (ED_<50>). Chitosanoligosaccharide > chitinoligosaccharide > aspirin 2. The inhibitory activity of tested drugs to both cyclooxygenase (COX)-1 and 2 was estimated to be in the following order, calculated from 50% inhibitory concentration (IC_<50>). Chitosanoligosaccharide > aspirin > chitinoligosaccharide 3. The selectivity of COX-1 and 2 was estimated to be in the following order, judging from COX-1(IC_<50>)/COX-2(IC_<50>) calculation. Chitinoligosaccharide > chitosanoligosaccharide > aspirin 4. The analgesic activity for acute inflammatory pain was estimated to be in the following order, calculated from ED_<50>. Chitinoligosaccharide > chitosanoligosaccharide > aspirin 5. It was seemed that anti-inflammatory effects of chitosanoligosaccharide on mice gingivae was more than aspirin. Based on these pharmacological findings, it was clarified that chitinoligosaccharide had greater analgesic activity and fewer side effects, based on the inhibited COX-1, than the other tested drugs, and chitosanoligosaccharide had greater inhibitory activity of vascular permeability and greater inhibitory activity of COX-2, based on causing inflammation, than the other tested drugs. | |||||
| 雑誌書誌ID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN1010214X | |||||
| 書誌情報 |
奥羽大学歯学誌 巻 30, 号 2, p. 115-126, 発行日 2003-06-30 |
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